The Epilepsy Centre Hessen (ECH) is one of the main epilepsy centres in Germany and the only one in the state of Hessen (6.2 million inhabitants). It consists of a clinical branch with all diagnostic and therapeutic methods including presurgical diagnosis, stereo-EEG, resective epilepsy surgery, vagus-nerve stimulator (VNS) and deep brain stimulation (DBS). The ECH is directed by Prof. F. Rosenow who was member of the surgical task force of the ILAE and is secretary of the tri-national Epilepsy Surgery Working Group (www.ag-epilepsiechirurgie.de). He has unique experience in organizing large controlled multi-centre therapy trials. He initiated and participated in the EPICURE Consortium (FP6) and is partner in the Eurocores Programme EuroEPINOMICS, both highly successful European network consortia involved in epilepsy research. Prof. Rosenow is an expert on clinical and translational epilepsy trials including genetics and has published >120 peer-reviewed articles including publications in Brain, Neurology, Annals of Neurology and Nature Genetics. The section of experimental epileptology (headed byS. Bauer) of the ECH uses toxin free rat and mouse models of mesial temporal lobe epilepsy with hippocampal sclerosis. Methods comprise stereotaxic electrode implantation, electrical stimulation of different rodent brain areas, recording of stimulation-evoked potentials, long-term video EEG monitoring, tissue histology including immunostaining. 

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